Drugs with Adverse Reactions

What is Adverse drug reactions,
Adverse drug reactions (ADRs), defined as ‘the unwanted effects of drugs occurring under normal conditions of use’, are a significant cause of morbidity and mortality. Around 5% of acute medical emergencies are
dmitted with ADRs, and around 10–20% of hospital inpatients suffer an ADR during their stay. Unwanted effects of drugs are five to six times more likely in the elderly than in young adults; and the risk of an ADR rises sharply with
the number of drugs administered.
dmitted with ADRs, and around 10–20% of hospital inpatients suffer an ADR during their stay. Unwanted effects of drugs are five to six times more likely in the elderly than in young adults; and the risk of an ADR rises sharply with
the number of drugs administered.
Look at the following Drugs and their Adverse Reactions.
Examples of adverse drug reactions
Type of reaction and drug Adverse reaction
|
|
Type A (augmented)
|
|
ACE
inhibitors |
Hypotension
Chronic cough
|
ACE
antagonists |
Hypotension
|
Anticoagulants
|
Gastrointestinal
bleeding Intracerebral
haemorrhage |
Antipsychotics
|
Acute
dystonia/dyskinesia Parkinsonian
symptoms Tardive
dyskinesia |
Cytotoxic
agents |
Bone marrow
dyscrasias Cancer
|
Erythromycin
|
Nausea,
vomiting |
Glucocorticosteroids
|
Hypoadrenalism
Osteoporosis
|
Insulin
|
Hypoglycaemia
|
Tricyclic
antidepressants |
Dry mouth
|
Type B (bizarre)
|
|
Benzylpenicillin
Radiological contrast media |
Anaphylaxis
|
Broad-spectrum
penicillins |
Maculopapular
rash |
Carbamazepine
Lamotrigine Phenytoin
Sulphonamides |
Toxic
epidermal necrolysis
Stevens–Johnson
syndrome |
Carbamazepine
Diclofenac
Isoniazid
Phenytoin
Rifampicin
|
Hepatotoxicity
|
Isotretinoin
SSRIsa
|
Depression
Suicidal
ideation |
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