Drugs with Adverse Reactions

May 3, 2016 Drugs No comments

What is Adverse drug reactions,

Adverse drug reactions (ADRs), defined as ‘the unwanted effects of drugs occurring under normal conditions of use’, are a significant cause of morbidity and mortality. Around 5% of acute medical emergencies are
dmitted with ADRs, and around 10–20% of hospital inpatients suffer an ADR during their stay. Unwanted effects of drugs are five to six times more likely in the elderly than in young adults; and the risk of an ADR rises sharply with
the number of drugs administered.

Look at the following Drugs and their Adverse Reactions.

Examples of adverse drug reactions Type of reaction and drug Adverse reaction
Type A (augmented)
ACE inhibitors	Hypotension Chronic cough
ACE antagonists	Hypotension
Anticoagulants	Gastrointestinal bleeding Intracerebral haemorrhage
Antipsychotics	Acute dystonia/dyskinesia Parkinsonian symptoms Tardive dyskinesia
Cytotoxic agents	Bone marrow dyscrasias Cancer
Erythromycin	Nausea, vomiting
Glucocorticosteroids	Hypoadrenalism Osteoporosis
Insulin	Hypoglycaemia
Tricyclic antidepressants	Dry mouth
Type B (bizarre)
Benzylpenicillin Radiological contrast media	Anaphylaxis
Broad-spectrum penicillins	Maculopapular rash
Carbamazepine Lamotrigine Phenytoin Sulphonamides	Toxic epidermal necrolysis Stevens–Johnson syndrome
Carbamazepine Diclofenac Isoniazid Phenytoin Rifampicin	Hepatotoxicity
Isotretinoin SSRIsa	Depression Suicidal ideation