Drugs with Adverse Reactions
What is Adverse drug reactions,
Adverse drug reactions (ADRs), defined as ‘the unwanted effects of drugs occurring under normal conditions of use’, are a significant cause of morbidity and mortality. Around 5% of acute medical emergencies are
dmitted with ADRs, and around 10–20% of hospital inpatients suffer an ADR during their stay. Unwanted effects of drugs are five to six times more likely in the elderly than in young adults; and the risk of an ADR rises sharply with
the number of drugs administered.
dmitted with ADRs, and around 10–20% of hospital inpatients suffer an ADR during their stay. Unwanted effects of drugs are five to six times more likely in the elderly than in young adults; and the risk of an ADR rises sharply with
the number of drugs administered.
Look at the following Drugs and their Adverse Reactions.
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Examples of adverse drug reactions
Type of reaction and drug Adverse reaction
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Type A (augmented)
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ACE
inhibitors |
Hypotension
Chronic cough
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ACE
antagonists |
Hypotension
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Anticoagulants
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Gastrointestinal
bleeding Intracerebral
haemorrhage |
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Antipsychotics
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Acute
dystonia/dyskinesia Parkinsonian
symptoms Tardive
dyskinesia |
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Cytotoxic
agents |
Bone marrow
dyscrasias Cancer
|
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Erythromycin
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Nausea,
vomiting |
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Glucocorticosteroids
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Hypoadrenalism
Osteoporosis
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Insulin
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Hypoglycaemia
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Tricyclic
antidepressants |
Dry mouth
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Type B (bizarre)
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Benzylpenicillin
Radiological contrast media |
Anaphylaxis
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Broad-spectrum
penicillins |
Maculopapular
rash |
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Carbamazepine
Lamotrigine Phenytoin
Sulphonamides |
Toxic
epidermal necrolysis
Stevens–Johnson
syndrome |
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Carbamazepine
Diclofenac
Isoniazid
Phenytoin
Rifampicin
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Hepatotoxicity
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Isotretinoin
SSRIsa
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Depression
Suicidal
ideation |