Antibiotic: Fluoroquinolones Uses, Dosage Range & Side Effects

Antibiotic: Fluoroquinolones

USES

Fluoroquinolones act against a wide range of gram-negative and gram-positive organisms. They are used primarily in the treatment of lower respiratory infections, skin/skin structure infections, urinary tract infections, and sexually transmitted diseases.

Antibiotic: Fluoroquinolones

NameAvailabilityDosage RangeSide Effects
Ciprofloxacin
(Cipro)
T: 100 mg, 250 mg, 500 mg, 750 mg
S: 250 mg/5 ml, 500 mg/5 ml
I: 200 mg, 400 mg
A (PO): 250–750 mg q12h;
(IV): 200–400 mg q12h
Dizziness, headaches, anxiety, drowsiness,
insomnia, abdominal pain, nausea, diarrhea,
vomiting, phlebitis (parenteral)
Gemifloxacin (Factive)

Levofloxacin (Levaquin)
T: 320 mg

T: 250 mg, 500 mg, 750 mg
I: 250 mg, 500 mg, 750 mg
OS: 250 mg/10 ml
A: 320 mg once daily


A (PO/IV): 250–750 mg/day
as single dose
Headache, dizziness, rash, diarrhea, nausea

Headache, insomnia, dizziness, rash, nausea,
diarrhea, constipation
Moxifloxacin (Avelox)T: 400 mg
I: 400 mg
A: 400 mg/dayHeadache, dizziness, insomnia, nausea, diarrhea
Norfloxacin (Noroxin)T: 400 mgA: 400 mg q12hDizziness, headaches, anxiety, drowsiness,
insomnia, abdominal pain, nausea, diarrhea,
vomiting, phlebitis (parenteral)
OfloxacinT: 200 mg, 300 mg, 400 mgA: 200–400 mg q12hDizziness, headache, insomnia, abdominal
cramps, diarrhea, nausea

ACTION

Bactericidal. Inhibit DNA gyrase in susceptible microorganisms, interfering with bacterial DNA replication and repair.

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