Magnesium Sulfate MGSO4 Toxicity Pharmacology Mnemonic

Magnesium sulfate is a small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions.

Magnesium sulfate is gaining popularity as an initial treatment in the management of various dysrhythmias, particularly torsades de pointes, and dyrhythmias secondary to TCA overdose or digitalis toxicity.

mg-so4-toxicity

If Magnesium toxicity occurs: stop MGSO4 infusion and administer antidote of calcium gluconate (10ml of 10% solution slowly intravenously over approx. 10 min)

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