NAPLEX Practice Question # 75

NAPLEX Examination.

Practice Question # 75.


 

naplex

 

aspirin adverse effects

 

 

 

 

 

 

 

 

 

 

 

Adverse effects

  • Gastrointestinal (GI) eff ects. Most nonnarcotic analgesics cause GI symptoms secondary to prostaglandin inhibition. At normal doses, acetaminophen and choline magnesium trisalicylate produce minimal GI upset. Because of their mechanism of action, the COX-2 inhibitors have a GI toxicity similar to placebo. Adalimumab, etanercept, infl iximab, and lefl unomide have been associated with GI side eff ects including nausea, abdominal pain, dyspepsia, constipation, vomiting, hematochezia, intestinal obduction, intestinal perforation, pancreatitis, peritonitis, peptic ulcer, and diarrhea.
  • Th e most common GI symptom is dyspepsia, but ulceration, bleeding, or perforation can occur.
  • Patients most predisposed to severe GI eff ects include the elderly, patients with a history of ulcers or chronic disease, and those who smoke or use alcohol.
  • To minimize GI eff ects, the lowest possible analgesic dose should be used. Aspirin, available as enteric-coated products, may minimize GI upset. Combination therapy with a GI “protectant” (e.g., antacid, H2-antagonist, sucralfate, misoprostol) may be needed.

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