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Morphine sulphate Pharmacology Review.
- Moderate to severe pain
- Binds with opioid receptors in the CNS, altering perception of and emotional response to pain.
CNS: dizziness, euphoria, light-headedness, nightmares, sedation, somnolence, seizures, syncope
CV: bradycardia, cardiac arrest, shock, hypertension, hypotension, tachycardia
GI: constipation, nausea, vomiting, anorexia, biliary tract spasms, dry mouth, ileus
Respiratory: apnea, respiratory arrest, respiratory depression
Reassess patient’s level of pain at least 15 and 30 minutes after giving parenterally and 30 minutes after giving orally. Keep opioid antagonist (naloxone) and resuscitation equipment available. Monitor circulatory, respiratory, bladder, and bowel functions carefully. Preservative-free preparations are available for epidural and intrathecal use. When drug is given epidurally, monitor patient closely for respiratory depression up to 24 hours after the injection. Don’t confuse morphine with hydromorphone or Avinza with Invanz.