Therapeutic and Toxic, Drug Levels

Therapeutic and Toxic, Drug Levels  According to the Conventional (US System of Measurements), save this chart when Drug levels become complicated.

Therapeutic and Toxic, Drug Levels
Drug
Therapeutic Level
Toxic Level
Acetaminophen
5–20 ug/mL
>40 ug/mL
Alprazolam
10–50 ng/mL
>75 ng/mL
Amikacin
peak: 20–30 ug/mL
trough: 4–8 ug/mL
peak: >35 ug/mL
trough: >10 ug/mL
Aminocaproic
acid
100–400 ug/mL
>400 ug/mL
Aminophylline
10–20 ug/mL
>20 ug/ml
Amiodarone
0.5–2.5 ug/mL
>2.5 ug/mL
Amitriptyline
120–150 ng/mL
>500 ng/ml
Amoxapine
200–400 ng/mL
>500 ng/mL
Atenolol
200–500 ng/mL
>500 ng/mL
Aepridil
HCl
1–2 ng/mL
>2 ng/mL
Arbamazepine
5–12 ug/mL
>12 ug/mL
Chloral
hydrate
2–12 ug/mL
>20 ug/mL
Chloramphenicol
10–20 ug/mL
>25 _g/mL
Chlordiazepoxide
1–5 ug/mL
>5 ug/mL
Chlorpromazine
50–300 ng/mL
>750 ng/mL
Chlorpropramide
75–250 ug/mL
>250 ug/mL
Clonazepam
15–60 ng/mL
>80 ng/mL
Cyclosporine
100–300 ng/mL
<85 or >500 ng/mL
Desipramine
150–300 ng/mL
>500 ng/mL
Diazepam
0.5–2 mg/L
>3 mg/L
Digoxin
0.8–2 ng/mL
>2 ng/mL
Diltiazem
50–200 ng/mL
>200 ng/mL
Disopyramide
2–5 ug/mL
>7 ug/mL
Doxepin
150–300 ng/mL
>400 ng/mL
Ethosuximide
40–100 ug/mL
>150 ug/mL
Flecainide
0.2–1 ug/mL
>1 ug/mL
Gentamicin
peak: 6–10 ug/mL
trough:<  2 ug/mL
peak: 12 ug/mL
trough: > 2 ug/mL
Haloperidol
3–20 ng/mL
>42 ng/mL
Hydromorphone
1–30 ng/mL
>100 ng/mL
Imipramine
150–300 ng/mL
>500 ng/mL
Kanamycin
20–25 ug/mL
>35 ug/mL
Lidocaine
1.5–5 ug/mL
>5 ug/mL
Lithium
0.5–1.5 mEq/L
>1.5 mEq/L
Meperidine
0.4–0.7 ug/mL
>1 ug/mL
Methotrexate
_>0.01 umol
>10 umol in 24 hr
Mexiletine
0.5–2 ug/mL
>2 ug/mL
Mezlocillin
sodium
35–45 ug/mL
>45 ug/mL
Milrinone
150–250 ng/mL
>250 ng/mL
Morphine
10–80 ng/mL
>200 ng/mL
Nicardipine
0.028–0.05 ug/mL
>0.05 ug/mL
Nifedipine
0.025–0.1 ug/mL
>0.1 ug/mL
Nortriptyline
50–150 ng/mL
>500 ng/mL
Phenobarbital
15–30 ug/mL
>40 ug/mL
Phenytoin
10–20 ug/mL
>20 ug/mL
Primidone
5–12 ug/mL
>12 ug/mL
Procainamide
4–10 ug/mL
>10 ug/mL
Propafenone
0.5–3 ug/mL
>3 ug/mL
Propranolol
50–100 ng/m
>150 ng/mL
Quinidine
2–5 ug/mL
>6 ug/mL
Salicylate
10–30 mg/dL
>35 mg/dL
Theophylline
10–20 ug/mL
>20 ug/mL
Tobramycin
peak:
6–10 ug/mL
trough:
< 2 ug/mL
peak:
>12  ug/mL
trough:>2
ug/mL
Tocainide
HCl
4–10 ug/mL
>12 ug/mL
Trazadone
500–2000 ng/mL
>4000 ng/mL
Valproic
acid
50–100 ug/mL
>100 ug/mL
Vancomycin
peak:
20–40  ug/mL
trough:
5–10  ug/mL
peak:
> 80  ug/mL
trough:
>10  ug/mL
Verapamil
0.08–0.3
ug/mL
0.3
> ug/mL

Share with friends who could use this when Drug levels become complicated.

Leave a Reply

Follow Us

Follow us on Facebook