Vilazodone inhibits CNS neuron serotonin uptake, with minima or no effect on reuptake of norepinephrine or dopamine. It binds selectively with high affinity to 5-HT1A receptors (altered in depression and anxiety patients) and is a 5-HT1A receptor partial agonist.
Efficacy Monitoring Parameters. Reduction in symptoms of depression
Toxicity Monitoring Parameters. Signs and symptoms of withdrawal upon abrupt dose reduction or discontinuation. Signs and symptoms of serotonin syndrome or akatheisia. Monitor or suicidal ideation.
Clinical Pearls. Safety and efficacy not established in pediatric patients <18 y o age.