Property of Heparin
- Platelet aggregation inhibitor
- Monoclonal antibody
- pH 7.2
Premedication: In all situations, premedication with histamine H2 antagonists (e.g., famotidine [Pepcid], ranitidine [Zantac]) may be appropriate; prophylaxis should be considered when certain conditions are present (e.g., patients with HACA antibodies, readministration of abciximab).
May cause major bleeding incidents (e.g., femoral artery or other access site, intracranial hemorrhage, spontaneous gross hematuria and other GU bleeds, spontaneous hematemesis and other GI bleeds, pulmonary hemorrhage, retroperitoneal bleeding). Decreases in hemoglobin greater than 5 Gm/dL or intracranial hemorrhage were defined as major during trials. Thrombocytopenia is common and may require platelet transfusion. Abdominal pain, back pain, bradycardia, chest pain, headache, hypotension, nausea, peripheral edema, positive HACA response, puncture site pain, and vomiting may occur.