Acetaminophen Dosing Guidelines

Acetaminophen ( ah-SEAT-ah-MIN-oh-fen)

  • Antipyretic
  • Analgesic
  • PH 5.5
  • Ofirmev

Acetaminophen Dosing


May be given as a single or repeated dose. Minimum dosing interval is 4 hours. No dose adjustment is necessary when converting from oral to IV dosing. The maximum daily dose of acetaminophen is based on all routes of administration (i.e., IV, oral, and rectal) and on all products containing acetaminophen.



Pediatric patients 2 to 12 years of age: 15 mg/kg every 6 hours or 12.5 mg/kg every 4 hours. Do not exceed a maximum single dose of 15 mg/kg or a maximum daily dose of  75€mg/kg/day. See comments under Usual Dose.



Adult patients:

The most common adverse reactions were headache, insomnia, nausea, and vomiting. Less frequently reported side effects included anxiety, dyspnea, fatigue, hypersensitivity reaction, hypertension, hypokalemia, hypotension, increased aspartate aminotransferase, infusion site pain, muscle spasms, peripheral edema, and trismus.

Pediatric patients:

The most common adverse reactions were agitation, atelectasis, constipation, nausea, pruritus, and vomiting. Less commonly reported side effects included abdominal pain, anemia, diarrhea, fever, headache, hypersensitivity reaction, hypertension, hypervolemia, hypoalbuminemia, hypokalemia, hypomagnesemia, hypophosphatemia, hypotension, hypoxia, increased hepatic enzymes, injection site pain, insomnia, muscle spasm, oliguria, pain in extremities, periorbital edema, peripheral edema, pleural effusion, pulmonary edema, rash, stridor, tachycardia, and wheezing.Overdose: Hepatic necrosis, renal tubular necrosis, hypoglycemic coma, and thrombocytopenia.Post-Marketing

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