Lisinopril is a prescription medication used to treat high blood pressure, congestive heart failure, and to improve survival after a heart attack. Lisinopril belongs to a group of drugs called angiotensin-converting enzyme (ACE) inhibitors, which relax blood vessels to lower blood pressure and make the heart pump more efficiently.
Lisinopril is a competitive ACE-I. It also reduces serum aldosterone, leading to decreased sodium retention, potentiates the vasodilator kallikrein–kinin system, and can alter prostanoid metabolism, inhibit the sympathetic nervous system, and inhibit the tissue renin–angiotensin system.
Lisinopril drug can cause serious side effects include:
• CNS: dizziness, headache, fatigue, paresthesia
• CV: orthostatic hypotension, hypotension, chest pain
• EENT: nasal congestion
• GI: diarrhea, nausea, dyspepsia
• Metabolic: hyperkalemia
• Respiratory: dyspnea; dry, persistent, tickling, nonproductive cough
• Other: angioedema
• Monitor blood pressure frequently. If drug doesn’t adequately control blood pressure, diuretics may be added.
• Don’t confuse lisinopril with fosinopril or Lioresal. Don’t confuse Zestril with Zostrix, Zetia, Zebeta, or Zyrtec. Don’t confuse Prinivil with Proventil or Prilosec.
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