NAPLEX Examination.
Practice Question.
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Naplex
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1. Question
The use of misoprostol to prevent nonsteroidal antiinfl ammatory drug–induced ulcers could cause all of the following side effects except,
Correct
Answer & Explanation:
The answer is C
As noted in the answer to question 7, most prostaglandin analogs have activity at receptors throughout the body, causing a prostaglandin-like eff ect on numerous organ systems. Misoprostol, as a relatively nonselective agonist, would cause contraction of gastrointestinal smooth muscle, stimulate pain fi bers, and reset the thermoregulatory center of the CNS, thus causing all the potential side eff ects listed except hypertension. Hypotension is more commonly observed.
Incorrect
Answer & Explanation:
The answer is C
As noted in the answer to question 7, most prostaglandin analogs have activity at receptors throughout the body, causing a prostaglandin-like eff ect on numerous organ systems. Misoprostol, as a relatively nonselective agonist, would cause contraction of gastrointestinal smooth muscle, stimulate pain fi bers, and reset the thermoregulatory center of the CNS, thus causing all the potential side eff ects listed except hypertension. Hypotension is more commonly observed.
Adverse effects associated with PGE1 and PGE1 analogs include diarrhea, abdominal pain, facial flushing, hypotension, headache, abortion, and pain associated with administration of the erectile dysfunction agents.
