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1. Question
Which of the following antigout medications is specifically used in acute attacks?
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Answer & Explanation:
The correct answer is A
Allopurinol, probenecid, pegloticase, and febuxostat, although effective in preventing attacks of gouty arthritis by lowering circulating levels of uric acid, are not effective in treating the acute infl ammatory situation that characterizes an acute attack. Colchicine, by inhibiting the migration of proinflammatory cells into the affected joint, will reduce the inflammatory process, thus alleviating the pain and edema associated with acute attacks of gouty arthritis.
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Answer & Explanation:
The correct answer is A
Allopurinol, probenecid, pegloticase, and febuxostat, although effective in preventing attacks of gouty arthritis by lowering circulating levels of uric acid, are not effective in treating the acute infl ammatory situation that characterizes an acute attack. Colchicine, by inhibiting the migration of proinflammatory cells into the affected joint, will reduce the inflammatory process, thus alleviating the pain and edema associated with acute attacks of gouty arthritis.
Colchicine is used for the treatment of acute gout attacks and usually provides relief to the pain and inflammation within 24 hrs. Colchicine is also marketed in combination products with probenecid (see section V.C) for the treatment of gout.