NAPLEX Practice Question # 12

NAPLEX Examination:

Take this Practice Question for your upcoming exam.


Naplex Practice Questions

Hydralazine (Various) NAPLEX Review


Hydralazine directly relaxes arterioles, decreasing systemic vascular resistance. It is also used intravenously or intramuscularly in managing hypertensive crisis.

Precautions and monitoring eff ects

  • Because hydralazine triggers compensatory reactions that counteract its antihypertensive eff ects, it is most useful when combined with a -blocker, central -agonist, or diuretic as a latter-step agent.
  • Refl ex tachycardia is common and should be considered before initiating therapy.
  • Hydralazine may induce angina, especially in patients with coronary artery disease and those not receiving a -blocker.
  • Drug-induced systemic lupus erythematosus (SLE) may occur.

(i) Baseline and serial complete blood counts (CBCs) with antinuclear antibody titers should be followed routinely to detect SLE. (ii) Slow acetylators of this drug have an increased incidence of SLE. Th eir risk may be reduced by administering doses of  200 mg/day.

(iii) Fatigue, malaise, low-grade fever, and joint aches may signal SLE.

  • Other adverse eff ects may include headache, peripheral neuropathy, nausea, vomiting, fl uid retention, and postural hypotension.

The usual daily dose is 25 to 100 mg.

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