NAPLEX Practice Question # 46

NAPLEX Examination.

Practice Question # 46.




Acetaminophen (APAP)

Acetaminophen (APAP) is considered fi rst-line therapy by the ACR for OA. It has excellent analgesic and antipyretic activity, but no anti-infl ammatory effects.

  • A dose of 4 g/day is recommended to avoid toxicity. Concomitant use of other medications with acetaminophen should be evaluated closely to avoid overdose.
  • Hepatotoxicity can occur in patients taking 4 g APAP a day. Symptoms can include nausea, vomiting, abdominal pain, malaise, and diaphoresis.
  • Because there is little, if any, infl ammation in the OA joint, APAP has been shown to be equally effi cacious as ibuprofen and naproxen in patients with mild to moderate OA pain.
  • Studies have shown either APAP immediate-release or extended-release is eff ective in treating mild to moderately severe OA pain.

Leave a Reply