NAPLEX Practice Question # 74

NAPLEX Examination.

Practice Question # 74.



chemotherapy agents











Drugs associated with necrosis of tissue are called vesicants. Local tissue necrosis may result from extravasation of vesicant chemotherapeutic agents outside the vein and into the subcutaneous tissue during administration.

  • Most vesicant extravasations produce immediate pain or burning. However, a delayed reaction may occur hours to weeks later. Signifi cant tissue injury, including ulceration or necrosis, may require plastic surgery intervention.
  • Th e treatment of extravasations varies, depending on the vesicant. Heat or cold packs and chemicals such as hyaluronidase or dexrazoxane (Totect) may be used.
  • Examples of vesicant agents include dactinomycin, daunorubicin, doxorubicin, idarubicin, mechlorethamine, mitomycin, vinblastine, vincristine, and vinorelbine.
  • Some agents are classifi ed as irritants (e.g., etoposide) and can cause irritation but not necessarily necrosis when extravasated.

Leave a Reply