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1. Question
Which of the following antiarrhythmic agents is most likely to cause pulmonary fibrosis during therapy?
Correct
Answer & Explanation:
The answer is C
Of all the drugs on the list, amiodarone is most likely to cause life-threatening pulmonary fibrosis.
Incorrect
Answer & Explanation:
The answer is C
Of all the drugs on the list, amiodarone is most likely to cause life-threatening pulmonary fibrosis.
The most significant adverse effect of these agents is the potential to cause torsades de pointes arrhythmias by virtue of their K channel blocking activity. Amiodarone has also caused lethal pulmonary fibrosis, microcrystalline corneal deposits, and photosensitivity. Dronedarone may be associated with hepatotoxicity, whereas amiodarone, dronedarone, and sotalol may also cause heart block and bradycardia and exacerbate heart failure.