NBDE Examination Practice Question # 109

NBDE Examination.
Practice Question # 109.


nbde quiz


Local anesthetics are widely used to prevent or treat acute pain; to treat inflammatory, cancer related, and chronic pain; and for diagnostic and prognostic purposes. Drugs classified as local anesthetics reversibly block action potential propagation in axons by preventing the sodium entry that produces the potentials [1]. Other actions of these drugs, however, such as anti-inflammatory actions by interaction with G-protein receptors [2], are also thought to be relevant to their use to prevent or treat pain. Both nociceptive and neuropathic pain are targeted by this group of drugs. Any part of the nervous system, from the periphery to the brain, may be where local anesthetics act to produce a desired anesthetic or analgesic effect. A variety of formulations of local anesthetics, routes of administration, and methods of administration are used.


The drugs are formulated commercially or by medical personnel according to intended route of administration or to address specific concerns or needs. In this article I provide a concise review of the pharmacology of local anesthetics with an emphasis on current concepts.

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