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NBDE Quiz # 24
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1. Question
The following drugs act as an agonist on mu ([1])Receptors in the central nervous system (CNS) for analgesia, except:
Correct
The correct answer is D. Ibuprofen is a nonsteroidal anti-inflammatory drug. It is believed to work through inhibition of cyclooxygenase (COX), thus inhibiting prostaglandin synthesis. Fentanyl is a synthetic primary [1] agonist opioid, currently the most widely used synthetic opioid analgesic worldwide, with a primary potency approximately 81 times that of morphine. Tramadol is a monoamine uptake inhibitor and centrally acting analgesic, used for treating moderate-to-severe pain. It is a synthetic agent, and it appears to have actions at the[1]-opioid receptor as well as the noradrenergic and serotonergic systems. Meperidine acts as an agonist at the [1]-opioid receptor. In addition to its strong opioidergic and anticholinergic effects, it has local anesthetic activity related to its interactions with sodium ion channels.
Incorrect
The correct answer is D. Ibuprofen is a nonsteroidal anti-inflammatory drug. It is believed to work through inhibition of cyclooxygenase (COX), thus inhibiting prostaglandin synthesis. Fentanyl is a synthetic primary [1] agonist opioid, currently the most widely used synthetic opioid analgesic worldwide, with a primary potency approximately 81 times that of morphine. Tramadol is a monoamine uptake inhibitor and centrally acting analgesic, used for treating moderate-to-severe pain. It is a synthetic agent, and it appears to have actions at the[1]-opioid receptor as well as the noradrenergic and serotonergic systems. Meperidine acts as an agonist at the [1]-opioid receptor. In addition to its strong opioidergic and anticholinergic effects, it has local anesthetic activity related to its interactions with sodium ion channels.
