NBDE Quiz # 34
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NBDE Quiz # 34
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1. Question
Which factor determines local anesthetic onset time?
CorrectThe correct answer is D. Answer choice D is correct because the closer the pKa (the pH at which the ionized and unionized forms exist in equal concentrations) of the local anesthetic is to tissue pH, the more rapid the onset time.
Answer choice A is incorrect; the lipid solubility affects the potency; the higher the solubility, the greater the potency. Answer choice B is incorrect because the protein binding influences the duration of action not the timing of onset. Answer choice C is incorrect because a vasoconstrictor influences length of anesthetic duration.IncorrectThe correct answer is D. Answer choice D is correct because the closer the pKa (the pH at which the ionized and unionized forms exist in equal concentrations) of the local anesthetic is to tissue pH, the more rapid the onset time.
Answer choice A is incorrect; the lipid solubility affects the potency; the higher the solubility, the greater the potency. Answer choice B is incorrect because the protein binding influences the duration of action not the timing of onset. Answer choice C is incorrect because a vasoconstrictor influences length of anesthetic duration.