NCLEX Quiz # 984

NCLEX Examination.

Practice Question # 984.


nclex quiz



Trade Name: generic, Imodium ®

Drug Class: Antidiarrheal, Opioid Agonist (OTC, non-prescription)

Mechanism of Action:

  • Opioid agonist
  • Does not cross the blood-brain barrier, has no analgesic or addictive properties)
  • inhibits the release of acetylcholine and prostaglandins, thereby reducing peristalsis, and increasing intestinal transit time, which also favorably affects water and electrolyte movement through the bowel.
  • increases the tone of the anal sphincter, reducing incontinence and urgency.



  • Mild to moderate diarrhea
  • Diarrhea associated with Inflammatory Bowel Disease (IBD)
  • Off label1): Irritable Bowel Syndrome with predominant diarrhea (IBS-D)
  • NOTE: loperamide has been evaluated in three small controlled trials. Loperamide was found to be more effective than placebo for decreasing stool frequency & consistency in IBS-D, but was not effective for other symptoms such as bloating, abdominal discomfort, or global IBS symptoms .


  • Does not cross the blood brain barrier

Side Effects:

  • Has no analgesic effects & no potential for addiction

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