NCLEX RN Practice Question # 421

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  • Omalizumab (Xolair) is a recombinant DNAderived humanized immunoglobulin G (IgG) murine monoclonal antibody that selectively binds to IgE to limit the release of mediators in the allergic response.
  • Used to treat allergy-related asthma; administered subcutaneously every 2 to 4 weeks
  • Dose is titrated based on the serum IgE level and body weight.
  • Contraindicated in those with hypersensitivity to the medication

 Side effects

  • Injection site reactions
  • Viral infections
  • Upper respiratory infections
  • Sinusitis
  • Headache
  • Pharyngitis
  • Anaphylaxis
  • Malignancies


  • Assess respiratory rate, rhythm, and depth and auscultate lung fields bilaterally.
  • Assess for allergies and/or allergic reaction symptoms such as rash or urticaria.
  • Instruct the client that respiratory improvement will not be immediate.
  • Instruct the client not to stop taking or decrease the currently prescribed asthma medications unless instructed.
  • Avoid live virus vaccines for the duration of treatment.
  • Have medications for the treatment of severe hypersensitivity reactions available during ini

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