NCLEX RN Practice Question # 421
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MONOCLONAL ANTIBODY
Description
- Omalizumab (Xolair) is a recombinant DNAderived humanized immunoglobulin G (IgG) murine monoclonal antibody that selectively binds to IgE to limit the release of mediators in the allergic response.
- Used to treat allergy-related asthma; administered subcutaneously every 2 to 4 weeks
- Dose is titrated based on the serum IgE level and body weight.
- Contraindicated in those with hypersensitivity to the medication
Side effects
- Injection site reactions
- Viral infections
- Upper respiratory infections
- Sinusitis
- Headache
- Pharyngitis
- Anaphylaxis
- Malignancies
Interventions
- Assess respiratory rate, rhythm, and depth and auscultate lung fields bilaterally.
- Assess for allergies and/or allergic reaction symptoms such as rash or urticaria.
- Instruct the client that respiratory improvement will not be immediate.
- Instruct the client not to stop taking or decrease the currently prescribed asthma medications unless instructed.
- Avoid live virus vaccines for the duration of treatment.
- Have medications for the treatment of severe hypersensitivity reactions available during ini