NCLEX RN Practice Question # 550
NCLEX Examination.
Practice Question # 550.
Nclex
ANTITUMOR ANTIBIOTIC MEDICATIONS
Description
- Interfere with DNA and RNA synthesis
- Cell cycle phase–nonspecific medications
Side effects
- Nausea and vomiting
- Fever
- Bone marrow depression
- Rash
- Alopecia
- Stomatitis
- Gonadal suppression
- Hyperuricemia
- Vesication (blistering of tissue at IV site)
- Daunorubicin (DaunoXome) may cause congestive heart failure and dysrhythmias.
- Doxorubicin (Adriamycin, Doxil) and idarubicin (Idamycin) may cause cardiotoxicity, cardiomyopathy,
- and electrocardiographic changes (Dexrazoxane [Zinecard] may be administered with doxorubicin to reduce cardiomyopathy).
- Pulmonary toxicity can occur with bleomycin (Blenoxane).
Interventions:
Refer to general interventions section under Antineoplastic Medications.
- Withhold medication if the platelets are lower than 75,000/mm3 or the neutrophil count is lower than 2000/mm3, and notify physician (this may vary depending on antitumor antibiotic agent and agency policy).
- Assess results of pulmonary function tests.
- Monitor for electrocardiographic changes.
- Assess lung sounds for crackles.
- Assess for signs of congestive heart failure, including dyspnea, crackles, peripheral edema, and weight gain.
- Assess results of chest radiography and renal and liver function studies.