NCLEX RN Practice Question # 609

NCLEX Examination.

Practice Question # 609.



Hepatitis B vaccine

Hepatitis B vaccine (HepB)

  • Protects against hepatitis B
  • Administered by the intramuscular route
  • First dose of hepatitis B vaccine (monovalent) should be administered soon after birth and before hospital discharge (the birth dose can be delayed in rare circumstances if the infant’s mother tests negative for hepatitis B surface antigen [HBsAg]).
  • Monovalent HepB or a combination vaccine containing hepatitis B may be used to complete the series.
  • The second dose is administered at age 1 to 2 months.
  • The final dose should be given at 24 weeks or older (6 to 18 months of age).
  • Contraindications: Severe allergic reaction to previous dose or vaccine component (components include aluminum hydroxide, yeast protein)
  • Precautions: An infant weighing less than 2000 g or an infant with moderate or severe acute illness with or without fever.

HBsAg-positive mothers

  • Infant should receive HepB vaccine and hepatitis B immunoglobulin (HBIG) within 12 hours of birth.
  • Infant should be tested for HBsAg and antibody to HBsAg after completion of HepB series (9 to 18 months of age).  Mother whose HBsAg status is unknown
  • Infant should receive the first dose of hepatitis vaccine series within 12 hours of birth.
  • Maternal blood should be drawn as soon as possible to determine the mother’s HBsAg status.
  • If the mother’s HBsAg test result is positive, the infant should receive HBIG as soon as possible (no later than 1 week of age).


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