NCLEX RN Practice Question # 610

NCLEX Examination.

Practice Question # 610.




metoclopramide (Reglan

Metoclopramide Pharmacology Review

  • Metoclopramide is a dopamine-receptor antagonist. Blockade of inhibitory dopamine receptors in the GI tract may allow stimulatory actions of ACh at muscarinic synapses to predominate. Metoclopramide also blocks dopamine D2-receptors within the CTZ.
  • This agent increases lower esophageal tone, stimulates gastric emptying, and increases the rate of transit through the small bowel.
  • Metoclopramide is used to treat reflux esophagitis, gastric motor failure, and diabetic gastroparesis; it is also used to promote placement of nasoenteric feeding tubes in critically ill patients.
  • Metoclopramide is also used as an antiemetic for nausea associated with chemotherapy (e.g., cisplatin and doxorubicin) and narcotic-induced vomiting.
  • Metoclopramide produces sedation, extrapyramidal effects, and increased prolactin secretion.

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