NCLEX RN Practice Question # 657

NCLEX Examination.

Practice Question # 657.


Some Important information about Isoniazid:


  • Bactericidal
  • Inhibits the synthesis of mycolic acids and
  • acts to kill actively growing organisms in the extracellular environment
  • Inhibits the growth of dormant organisms in the macrophages and caseating granulomas
  • Is active only during cell division and is used in combination with other antitubercular medications

Contraindications and cautions

  • Contraindicated in clientswith hypersensitivity or with acute liver disease
  • Use with caution in clients with chronic liver disease, alcoholism, or renal impairment.
  • Use with caution in clients taking nicotinic acid.
  • Use with caution in clients taking hepatotoxic medications because the risk for hepatotoxicity increases.
  • Alcohol increases the risk of hepatotoxicity.
  • May increase the risk of toxicity of carbamazepine and phenytoin
  • May decrease ketoconazole concentrations

Side and adverse effects

  • Hypersensitivity reactions
  • Peripheral neuritis
  • Neurotoxicity
  • Hepatotoxicity and hepatitis; increased liver function test levels
  • Pyridoxine deficiency
  • Irritation at injection site with intramuscular administration
  • Nausea and vomiting
  • Dry mouth
  • Dizziness
  • Hyperglycemia
  • Vision changes


  • Assess for hypersensitivity.
  • Assess for hepatic dysfunction.
  • Assess for sensitivity to nicotinic acid.
  • Monitor liver function test results.
  • Monitor for signs of hepatitis, such as anorexia, nausea, vomiting,weakness, fatigue, dark urine,

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