NCLEX RN Practice Question # 657
NCLEX Examination.
Practice Question # 657.
NCLEX Quiz
Some Important information about Isoniazid:
Description:
- Bactericidal
- Inhibits the synthesis of mycolic acids and
- acts to kill actively growing organisms in the extracellular environment
- Inhibits the growth of dormant organisms in the macrophages and caseating granulomas
- Is active only during cell division and is used in combination with other antitubercular medications
Contraindications and cautions
- Contraindicated in clientswith hypersensitivity or with acute liver disease
- Use with caution in clients with chronic liver disease, alcoholism, or renal impairment.
- Use with caution in clients taking nicotinic acid.
- Use with caution in clients taking hepatotoxic medications because the risk for hepatotoxicity increases.
- Alcohol increases the risk of hepatotoxicity.
- May increase the risk of toxicity of carbamazepine and phenytoin
- May decrease ketoconazole concentrations
Side and adverse effects
- Hypersensitivity reactions
- Peripheral neuritis
- Neurotoxicity
- Hepatotoxicity and hepatitis; increased liver function test levels
- Pyridoxine deficiency
- Irritation at injection site with intramuscular administration
- Nausea and vomiting
- Dry mouth
- Dizziness
- Hyperglycemia
- Vision changes
Interventions
- Assess for hypersensitivity.
- Assess for hepatic dysfunction.
- Assess for sensitivity to nicotinic acid.
- Monitor liver function test results.
- Monitor for signs of hepatitis, such as anorexia, nausea, vomiting,weakness, fatigue, dark urine,