Practice Question # 691.
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Colchicine is used for acute attacks of gout and prophylactic prevention of gout. Good relief of pain. It is often effective in aborting an attack when taken at the first sign of articular discomfort.
Exact mechanism unknown. In patients with gout, may interrupt the cycle o monosodium urate crystal deposition in joint tissues and the resultant in lammatory response that initiates and sustains an acute attack. Colchicine also inhibits urate crystal deposition, which is enhanced by a low pH in the tissues, probably by inhibiting oxidation o glucose and subsequent lactic acid production in leukocytes.
Adverse Reactions: Colchicine