NCLEX RN Practice Question # 723

NCLEX Examination.

Practice Question # 723.


NCLEX Examination.



Methotrexate is absorbed well and distributed throughout the body. It can accumulate in any fluid collection, such as ascites or pleural or pericardial effusion. This can result in prolonged elimination and higher-than-expected toxicity, especially myelosuppression.


Methotrexate reversibly inhibits the action of the enzyme dihydrofolate reductase. This blocks normal folic acid processing, which inhibits DNA and RNA synthesis. The result is cell death.

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