NCLEX RN Practice Question # 750

NCLEX Examination.

Practice Question # 750.

 

Nclex examination.

 

 

Deferoxamine:

Trade Name: Desferal ®

Drug Class: Iron Chelator

Mechanism of Action:

Binds iron avidly, but poorly binds other essential trace metals It competes in binding loosely bound iron, but fails to bind iron that is biologically chelated, such as in microsomal and mitrochondrial cytochromes and hemoproteins

Indications:

  • Iron poisoning. Used for treating both acute iron intoxication and in patients with secondary iron overload from multiple transfusions.
  • Deferoxamine plus hemodialysis may also be useful in treatment of aluminum toxicity in renal failure. (It is not indicated for the treatment of primary hemochromatosis, since phlebotomy is the method of choice for removing excess iron in this disorder.)

Contraindications:

Patients with severe renal disease or anuria, since the drug and the iron chelate are excreted primarily by the kidney.

Side Effects:

  • Rapid i.v. administration may cause hypotension
  • Idiosyncratic responses such as flushing, rash, abdominal discomfort may occur

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