NCLEX RN Practice Question # 785

NCLEX Examination.

Practice Question # 785.


nclex examination.


Isoniazid is taken up by mycobacterial cells and undergoes hydrolysis to isonicotinic acid, which reacts with cofactor nicotinamide adenine dinucleotide (NAD) to form a defective NAD that is no longer active as a coenzyme for certain life-sustaining reactions in the M. tuberculosis organism. Only replicating, not resting, bacteria appear to be inhibited.

Isoniazid is usually used with ethambutol, rifampin, or streptomycin. This is because combination therapy for TB and other mycobacterial infections can prevent or delay the development of resistance.

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