NCLEX RN Practice Question # 919

NCLEX Examination.

Practice Question # 919.

Warfarin (Coumadin) what you need to know,

Class: Anticoagulant, Vitamin K Antagonist

Dosage Forms. Oral Tablet: 1 mg, 2 mg, 2.5 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7.5 mg, 10 mg

Common FDA Label Indication, Dosing, and Titration.

• Multiple FDA-labeled indications, all dosed similarly, including atrial ibrillation; myocardial in arction; prosthetic cardiac valve component embolism; pulmonary embolism; thrombosis, postmyocardial in arction; venous thromboembolism: Initial, 2-5 mg po daily, adjust dose based on INR; usual maintenance 2-10 mg po daily

Off-Label Uses.

• Prevention o transient ischemic attacks: Initial, 2-5 mg po daily, adjust dose based on INR; usual maintenance 2-10 mg po daily

MOA. War arin prevents the conversion o vitamin K back to its active orm rom vitamin K epoxide. This impairs ormation o the vitamin K–dependent clotting actors II, VII, IX, and X (prothrombin) and proteins C and S (physiologic anticoagulants).